[IJPC - background info] Osmolarity: 2 grams of vancomycin added to 100 m L of 0.9% sodium chloride injection has a calculated osmolarity of 348 m Osm/L, however the actual osmolarity using an osmometer is much lower (~ 230) or HYPOTONIC.Further, vancomycin is very acidic - p H of ~ 3.4 (admixture). bags have demonstrated chemical stability (potency, p H of reconstituted solution and clarity of solution) for up to one week at refrigerated temperature. bags have demonstrated chemical stability (potency, p H of reconstituted solution and clarity of solution) for up to 24 hours at room temperature.
Are infusion volumes greater than 250ml required for larger doses??Calculated creatinine clearances (m L/min) are only estimates.The creatinine clearance should be measured promptly.Reconstituted solutions containing 1 g must be diluted with at least 200 m L of diluent.The desired dose, diluted in this manner, should be administered by intermittent intravenous infusion over a period of at least 60 minutes.
PREPARATION AND STABILITY At the time of use, reconstitute by adding either 10 m L of Sterile Water for Injection to the 500-mg vial or 20 m L of Sterile Water for Injection to the 1-g vial of dry, sterile vancomycin powder. After reconstitution with Sterile Water for Injection, 5% Dextrose Injection, or 0.9% Sodium Chloride Injection, the vials may be stored in a refrigerator for 14 days without significant loss of potency.